Negative Regulation of STAT3-mediated Cellular Respiration by SirT1

Negative Regulation of STAT3-mediated Cellular Respiration by SirT1 Michel Bernier‡, Rajib K. Paul‡, Alejandro Martin-Montalvo, Morten Scheibye-Knudsen, Shaoming Song, Hua-Jun He, Sean M. Armour, Vilhelm A. Bohr, Lili Wang, Yaping Zong, David A. Sinclair, and Rafael de Cabo From the Laboratory of Clinical Investigation, the Laboratory of Experimental Gerontology, the Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; National Institute of Standards and Technology, Gaithersburg, MD 20899, USA; Paul F. Glenn Laboratories, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA; and Full Moon Biosystems, Inc., Sunnyvale, CA 94085, USA. Running Title: STAT3 and cellular bioenergetics in SirT1-null cells Address correspondence to: Michel Bernier, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224. Phone: 410-558-8199, Fax: 410-558-8381; email: [email protected] or Rafael de Cabo, Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224. Phone: 410-5588510, Fax: 410-558-8302; email: [email protected]